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Butylphthalide is a clinical first-line drug for repairing nerve damage caused by stroke in China. It is a synthetic racemic n-butylphthalide, which has the same structure as natural L-apigenin A. Clinical research results show that butylphthalide can improve the damage of central nervous system in patients with acute ischemic stroke, and can promote the improvement of neurological deficits in patients. Animal pharmacodynamics studies have shown that butylphthalide can block multiple pathological links of brain injury caused by ischemic stroke, has a strong anti-cerebral ischemia effect, and can significantly reduce the infarct area of focal cerebral ischemia in rats , relieve cerebral edema, improve cerebral energy metabolism and microcirculation and blood flow in ischemic brain area, inhibit nerve cell apoptosis, and have anti-cerebral thrombosis and anti-platelet aggregation effects. Butylphthalide may exert the above-mentioned medicinal effects by reducing the content of arachidonic acid, increasing the levels of NO and PGI2 in cerebral vascular endothelium, inhibiting the release of glutamate, reducing the concentration of intracellular calcium, inhibiting free radicals and increasing the activity of antioxidant enzymes. .
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Recombinant Human Growth Hormone (HGH) API
Human growth hormone is a peptide hormone secreted by the anterior pituitary gland, which mainly regulates cell growth, regeneration, repair, reproduction and metabolism, thereby contributing to the overall development of the body. Growth hormone consists of 191 amino acids and has a molecular weight of 22KDa. Its functions mainly include: 1) It exerts its physiological function by stimulating the liver and other tissues to produce insulin-like growth factor (IGF-1), and promotes the growth of bone and cartilage, thereby increasing the body; 2) Affect metabolism, thereby promoting protein synthesis, and enhancing the intake and utilization of important elements such as sodium, potassium, calcium, phosphorus, and sulfur; 3) By inhibiting the consumption of sugar and accelerating the decomposition of fat, the energy source is changed from sugar metabolism to fat metabolism. The indications approved in China are: 1. For children with slow growth caused by endogenous growth hormone deficiency; 2. For severe burns to treat adult growth hormone deficiency. Approved indications in the United States are: 1. Growth hormone deficiency (GHD) in children; 2. Chronic renal insufficiency before kidney transplantation; 3. HIV infection-related failure syndrome; 4. Turner syndrome; 5. rhGH in anti-aging , weight loss; 6, liver failure; dilated cardiomyopathy; 7, burns, severe trauma, postoperative, total intravenous nutrition, etc.; 8, improve immune function; anti-aging, infertility.
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Ademetionine1,4-Butanedisulfonate (SAM)
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